Cymbalta also releases norepinephrine, which stops the movement of pain signals in the brain, helping to reduce sensations of pain in the body. Cymbalta is used to treat pain caused by diabetic neuropathy, fibromyalgia, and ongoing bone or muscle pain such as lower back pain or osteoarthritis.
A common side effect of Cymbalta is loss of appetite and weight loss. In addition to causing loss of appetite, taking Cymbalta may spur diarrhea and nausea, which can make patients eat less, therefore losing weight. According to eMedTV, clinical studies of Cymbalta have shown that up to 9 percent of people taking the medication reported a loss of appetite, and up to 2 percent of people reported weight loss.
People lost about 1 to 3 lbs. There are five main classes of antidepressants which affect these neurotransmitters in different ways:. Some mild side effects can occur within the first two weeks of starting the medication, but many will resolve after that. Most antidepressant medications are more commonly associated with weight gain, but there are three that have been connected to weight loss:.
Studies on the effect of fluoxetine Prozac on weight are varied, with only some people experiencing weight loss. And while it may cause weight loss in the short-term, but after six months or longer can lead to an increase in weight.
Similarly, the research on the impact of duloxetine Cymbalta on weight loss is unclear. Duloxetine can decrease appetite, which can lead to weight loss in some people.
However, research has yet to show a compelling and consistent connection between duloxetine Cymbalta and weight loss. Of these three medications, bupropion Wellbutrin is the most consistently associated with weight loss. Several studies, including a meta-analysis of 27 studies , found that bupropion Wellbutrin was the only commonly used antidepressant associated with weight loss.
Bupropion Wellbutrin , an atypical antidepressant, works by altering the brain chemicals norepinephrine and dopamine. Though most antidepressants can cause weight gain as side effect, some antidepressants seem more likely to cause weight gain than others, including:. Can depression actually cause hair loss? As with many antidepressants, stopping Cymbalta can cause some unpleasant side effects. Watching a friend live with depression can be painful, but there are ways to help.
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It is important to speak to a doctor before stopping the medication. Withdrawal symptoms can include:. Individuals taking Cymbalta and experiencing any side effects, including weight loss or gain, should speak to their doctor. While slight changes in body weight are not a cause for concern in most people, they may indicate an underlying health condition unrelated to antidepressant use.
Also, some research suggests that weight changes can affect the likelihood of a person continuing to follow their treatment plan. Overall, the benefits of taking Cymbalta for depression typically outweigh the effects of weight gain.
Doctors may recommend lifestyle changes, such as getting more regular exercise and following a balanced, calorie-controlled diet, to help people offset any weight gain. If these changes do not work, or if a person is experiencing other side effects, the doctor may recommend changing the dosage of Cymbalta or switching to another antidepressant.
There are many antidepressants that a doctor may suggest as an alternative to Cymbalta. These include:. Doctors do not commonly prescribe this older class of antidepressant drugs due to a higher risk of adverse reactions. However, MAOIs may be helpful for people who have had little success with other antidepressants. Examples of MAOIs include:.
These are among the oldest types of antidepressants. Today, doctors prescribe them much less commonly than newer classes of antidepressant drugs. Tricyclic antidepressants include:. Some research links Cymbalta with weight loss in the short-term and modest weight gain in the long-term. However, each person will react differently to the medication.
Treating depression is essential for health and well-being, and individuals should speak to their doctor about the best way to manage their symptoms. If Cymbalta or another antidepressant is causing weight changes or other side effects, discuss the options with a doctor. Sometimes, switching the dose or type of medication can make all the difference.
Other times, lifestyle changes can offset weight gain while also helping people manage symptoms of depression. Cymbalta, or duloxetine, is a serotonin-norepinephrine reuptake inhibitor for depression and neurological pain.
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